Comparative Evaluation of Ofloxacin Incorporated T-PRF vs Metronidazole Incorporated T-PRF as an Adjunct to Non Surgical Periodontal Therapy: A Randomized Controlled Clinical Trial
Prakash Pai Gurpur
Department of Periodontology and Oral Implantology, K.V.G Dental college and Hospital, Sullia, India.
Mundoor Manjunath Dayakar
Department of Periodontology and Oral Implantology, K.V.G Dental college and Hospital, Sullia, India.
S. S. Sarvapradha *
Department of Periodontology and Oral Implantology, K.V.G Dental college and Hospital, Sullia, India.
K. Anuswara
Department of Periodontology and Oral Implantology, K.V.G Dental college and Hospital, Sullia, India.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Non-surgical periodontal therapy (NSPT) remains the cornerstone in the management of periodontitis; however, complete elimination of subgingival pathogens through mechanical debridement alone is often limited. Local drug delivery systems combined with biologically active scaffolds may enhance therapeutic outcomes. Titanium-prepared platelet-rich fibrin (T-PRF), owing to its dense fibrin architecture and sustained release of growth factors, has emerged as a promising autologous biomaterial. Incorporation of antimicrobial agents such as ofloxacin and metronidazole into T-PRF may provide combined antimicrobial and regenerative benefits.
Aim: To evaluate and compare the clinical efficacy of ofloxacin-incorporated T-PRF and metronidazole-incorporated T-PRF as adjuncts to scaling and root planing (SRP) in the treatment of periodontitis.
Methodology: This randomized controlled clinical trial included thirty systemically healthy patients diagnosed with periodontitis were randomly allocated into three groups (n=10): Group I—SRP alone; Group II—SRP with ofloxacin-loaded T-PRF; and Group III—SRP with metronidazole-loaded T-PRF. Antimicrobial-loaded T-PRF membranes were placed sub-gingivally following SRP. Clinical parameters including plaque index, bleeding index, probing depth, and clinical attachment level were recorded at baseline, one month, and three months.
Results: All groups demonstrated significant improvement in clinical parameters over time with no adverse events reported. Both antimicrobial-loaded T-PRF groups showed greater reductions in probing depth and gains in clinical attachment compared to SRP alone. Ofloxacin-incorporated T-PRF demonstrated marginally superior outcomes compared to metronidazole-incorporated T-PRF at three months.
Conclusion: Antimicrobial-loaded T-PRF serves as an effective adjunct to NSPT, with ofloxacin-incorporated T-PRF showing enhanced clinical benefits in managing periodontitis.
Keywords: Local drug delivery, metronidazole, non-surgical periodontal therapy, ofloxacin, periodontitis, T-PRF