Cellular Senescence: A Cellular Decline and Its Correlation to Orthodontics
NAADIRA JAMALUDDIN
*
Centre of Paediatric Dentistry & Orthodontics Studies, Faculty of Dentistry, Universiti Teknologi MARA, Malaysia and Faculty of Dentistry, Universiti Sains Islam Malaysia, Malaysia.
NIK MUKHRIZ NIK MUSTAPHA
Centre of Paediatric Dentistry & Orthodontics Studies, Faculty of Dentistry, Universiti Teknologi MARA, Malaysia.
LUAY THANOON YOUNIS
Centre of Paediatric Dentistry & Orthodontics Studies, Faculty of Dentistry, Universiti Teknologi MARA, Malaysia.
AIDA NUR ASHIKIN ABD RAHMAN
Centre of Paediatric Dentistry & Orthodontics Studies, Faculty of Dentistry, Universiti Teknologi MARA, Malaysia.
SYATIRAH NAJMI ABDULLAH
Centre of Paediatric Dentistry & Orthodontics Studies, Faculty of Dentistry, Universiti Teknologi MARA, Malaysia and Faculty of Dentistry, Universiti Sains Islam Malaysia, Malaysia.
*Author to whom correspondence should be addressed.
Abstract
Cellular senescence is often characterized as having a dual nature, with both beneficial and detrimental aspects in various physiological processes. On one hand, it serves as a protective mechanism against cancer by suppressing the growth of damaged or pre-cancerous cells. The dual nature of cellular senescence, with both beneficial and detrimental aspects, underscores the complexity of its influence on health and disease. While it serves as a critical safeguard against cancer by suppressing the proliferation of damaged or pre-cancerous cells, the accumulation of senescent cells has also been implicated in the aging process and the development of age-related disorders. the role of cellular senescence in orthodontic treatment outcomes has been increasingly recognized. Aging of periodontal tissue cells, influenced by cellular senescence, can affect the success and stability of orthodontic interventions. The study highlights the need for personalized treatment strategies, especially for older patients, considering their age, overall health, and the degree of cellular senescence in their periodontal tissues. Further research is crucial to develop targeted interventions that mitigate the adverse effects of senescence on orthodontic treatment, potentially by modulating senescent cell behaviour or employing senotherapies.
Keywords: Cellular senescence, age-related disorders, functional transformations, homeostasis