Periostin: A Potential Biomarker for Periodontitis
Published: 2019-10-28
Page: 34-39
Issue: 2019 - Volume 2 [Issue 1]
Zeinab Rezaei Esfahrood
Department of Periodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Setareh Kazemi Veysari *
Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
*Author to whom correspondence should be addressed.
Abstract
Background: Periostin is among the most important extracellular matrix proteins, that seems to play a role in the healing of periodontal defects as a modulator of periodontal ligament (PDL) hemostasis. This study aims to review the available literature on this protein and its role in the healing of periodontal defects.
Methods: An electronic search of the literature was carried out in PubMed and Google Scholar using the keywords “periostin”, “gingival crevicular fluid”, “saliva” and “periodontitis”.
Results: Periostin, as an extracellular matrix protein, was found to play a key role as a modulator of critical cellular interactions in disease conditions. It is necessary for tissue integrity and plays a critical role in wound healing.
Conclusion: The role of periostin in cell proliferation, differentiation, migration and signalling to maintain hemostasis has yet to be identified. Further studies are warranted in this respect.
Keywords: Periostin, gingival crevicular fluid, saliva, periodontitis.